Copper and cuproptosis-related genes in hepatocellular carcinoma: therapeutic biomarkers targeting tumor immune microenvironment and immune checkpoints

BackgroundHepatocellular carcinoma (HCC), one of the most common cancers worldwide, exhibits high immune heterogeneity and mortality. Emerging studies suggest that copper (Cu) plays a key role in cell survival. However, the relationship between Cu and tumor development remains unclear.MethodsWe inve...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Xiaoqiang Wang, Dongfang Chen, Yumiao Shi, Jiamei Luo, Yiqi Zhang, Xiaohong Yuan, Chaojin Zhang, Huigang Shu, Weifeng Yu, Jie Tian
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	copper cuproptosis hepatocellular carcinoma immune checkpoints tumor immune microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1123231/full