Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation

Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Jiayu Sun, Jie Li, Hongbao Sun, Chunling Li, Haoxing Wu
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	functionalized cyclobutene analogues concise synthesis tetrazine ligation bioorthogonal chemistry
Online Access:	https://www.mdpi.com/1420-3049/26/2/276