Antifatigue Effects of 5-Aminolevulinic Acid Chronic Treatment on Mice

5-aminolevulinic acid (5-ALA) is a heme precursor involved in mitochondrial activation. A clinical study suggested that 5-ALA supplementation alleviates fatigue in healthy individuals who experience chronic physical tiredness. However, the detailed mechanisms are unknown. Therefore, we investigated...

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Bibliographic Details

Published in:	Life
Main Authors:	Chinatsu Ohmori, Eiko Kumamoto, Satoka Kasai, Kotaro Okano, Urara Ota, Atsuko Kamiya, Mitsugu Yamauchi, Kiwamu Takahashi, Masahiro Ishizuka, Kazumi Yoshizawa, Daisuke Yamada, Akiyoshi Saitoh
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	fatigue monoamine 5-aminolevulinic acid protoporphyrin IX MHPG noradrenaline
Online Access:	https://www.mdpi.com/2075-1729/15/9/1465