PR3-ANCAs Detected by Third-Generation ELISA Predicts Severe Disease and Poor Survival in Primary Sclerosing Cholangitis

A highly sensitive detection of anti-neutrophil cytoplasmic antibodies to serine proteinase-3 (PR3-ANCAs) aids in the serological diagnosis of autoimmune liver disorders and the prediction of severity in primary sclerosing cholangitis (PSC). Here, we evaluate a novel third-generation ELISA for the d...

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Bibliographic Details

Published in:	Diagnostics
Main Authors:	Steffi Lopens, Ewa Wunsch, Malgorzata Milkiewicz, Nadja Röber, Grit Zarske, Abdullah Nasser, Karsten Conrad, Martin Laass, Stefan Rödiger, Marcin Krawczyk, Dirk Roggenbuck, Piotr Milkiewicz
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	primary sclerosing cholangitis antibodies against serine protease proteinase-3 survival health-related quality of life liver biochemistry disease severity
Online Access:	https://www.mdpi.com/2075-4418/12/11/2682