Effects of Lithium Ions on tPA-Induced Hemorrhagic Transformation under Stroke

Thrombolytic therapy with the tissue plasminogen activator (tPA) is a therapeutic option for acute ischemic stroke. However, this approach is subject to several limitations, particularly the increased risk of hemorrhagic transformation (HT). Lithium salts show neuroprotective effects in stroke, but...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Valentina A. Babenko, Elmira I. Yakupova, Irina B. Pevzner, Alexey D. Bocharnikov, Ljubava D. Zorova, Kseniya S. Fedulova, Oleg A. Grebenchikov, Artem N. Kuzovlev, Andrey V. Grechko, Denis N. Silachev, Parvaneh Rahimi-Moghaddam, Egor Y. Plotnikov
Format:	Article
Language:	English
Published:	MDPI AG 2024-06-01
Subjects:	tissue plasminogen activator hemorrhagic transformation photothrombosis oxygen-glucose deprivation lithium salts
Online Access:	https://www.mdpi.com/2227-9059/12/6/1325