Centripetal cholesterol flow from the extrahepatic organs through the liver is normal in mice with mutated Niemann-Pick type C protein (NPC1)

Niemann-Pick type C (NPC) protein functions to move unesterified cholesterol from the lysosomal compartment to other intracellular sites for further metabolism and/or excretion. This cholesterol is brought into the cell through the coated-pit pathway and accumulates in the lysosomes when NPC protein...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Chonglun Xie, Stephen D. Turley, John M. Dietschy
Format:	Article
Language:	English
Published:	Elsevier 2000-08-01
Subjects:	Niemann-Pick type C disease scavenger receptor BI low density lipoprotein receptor coated pit lysosome high density lipoprotein
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520334362