Neuroendocrine transdifferentiation in human cancer: molecular mechanisms and therapeutic targets

Abstract Neuroendocrine transdifferentiation (NEtD), also commonly referred to as lineage plasticity, emerges as an acquired resistance mechanism to molecular targeted therapies in multiple cancer types, predominately occurs in metastatic epidermal growth factor receptor (EGFR)‐mutant non‐small cell...

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Bibliographic Details

Published in:	MedComm
Main Authors:	Jun Jiang, Donghui Han, Jiawei Wang, Weihong Wen, Rui Zhang, Weijun Qin
Format:	Article
Language:	English
Published:	Wiley 2024-10-01
Subjects:	acquired resistance lineage plasticity neuroendocrine prostate cancer neuroendocrine transdifferentiation small cell lung cancer
Online Access:	https://doi.org/10.1002/mco2.761