Histopathology based AI model predicts anti-angiogenic therapy response in renal cancer clinical trial

Abstract Anti-angiogenic (AA) therapy is a cornerstone of metastatic clear cell renal cell carcinoma (ccRCC) treatment, but not everyone responds, and predictive biomarkers are lacking. CD31, a marker of vasculature, is insufficient, and the Angioscore, an RNA-based angiogenesis quantification metho...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Jay Jasti, Hua Zhong, Vandana Panwar, Vipul Jarmale, Jeffrey Miyata, Deyssy Carrillo, Alana Christie, Dinesh Rakheja, Zora Modrusan, Edward Ernest Kadel, Niha Beig, Mahrukh Huseni, James Brugarolas, Payal Kapur, Satwik Rajaram
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Online Access:	https://doi.org/10.1038/s41467-025-57717-6