Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy

Abstract Loss of β‐cell number and function is a hallmark of diabetes. β‐cell preservation is emerging as a promising strategy to treat and reverse diabetes. Here, we first found that Pdia4 was primarily expressed in β‐cells. This expression was up‐regulated in β‐cells and blood of mice in response...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Tien‐Fen Kuo, Shuo‐Wen Hsu, Shou‐Hsien Huang, Cicero Lee‐Tian Chang, Ching‐Shan Feng, Ming‐Guang Huang, Tzung‐Yan Chen, Meng‐Ting Yang, Si‐Tse Jiang, Tuan‐Nan Wen, Chun‐Yen Yang, Chung‐Yu Huang, Shu‐Huei Kao, Keng‐Chang Tsai, Greta Yang, Wen‐Chin Yang
Format:	Article
Language:	English
Published:	Springer Nature 2021-09-01
Subjects:	diabetes Pdia4 ROS β‐cell failure β‐cells
Online Access:	https://doi.org/10.15252/emmm.201911668