Targeting of Janus Kinases Limits Pro-Inflammatory but Also Immunosuppressive Circuits in the Crosstalk between Synovial Fibroblasts and Lymphocytes

Crosstalk between synovial fibroblasts (SF) and immune cells plays a central role in the development of rheumatoid arthritis (RA). Janus kinase inhibitors (JAKi) have proven efficacy in the treatment of RA, although clinical responses are heterogeneous. Currently, little is known regarding how JAKi...

Full description

Bibliographic Details

Published in:	Biomedicines
Main Authors:	Nina Yao, Theresa Tretter, Peter Kvacskay, Wolfgang Merkt, Norbert Blank, Hanns-Martin Lorenz, Lars-Oliver Tykocinski
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	janus kinases JAK inhibitors tofacitinib baricitinib upadacitinib rheumatoid arthritis
Online Access:	https://www.mdpi.com/2227-9059/9/10/1413