The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer

Abstract Background The pattern recognition receptor long pentraxin-3 (PTX3) plays conflicting roles in cancer by acting as an oncosuppressor or as a pro-tumor mediator depending on tumor context. Triple negative breast cancer (TNBC) represents the most aggressive histotype of breast cancer, charact...

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Bibliographic Details

Published in:	Experimental Hematology & Oncology
Main Authors:	Arianna Giacomini, Marta Turati, Elisabetta Grillo, Sara Rezzola, Gaia Cristina Ghedini, Ander Churruca Schuind, Eleonora Foglio, Federica Maccarinelli, Jessica Faletti, Serena Filiberti, Angela Chambery, Mariangela Valletta, Laura Melocchi, Stephanie Gofflot, Barbara Chiavarina, Andrei Turtoi, Marco Presta, Roberto Ronca
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	PTX3 Triple negative breast cancer (TNBC) TLR4 signaling pathway
Online Access:	https://doi.org/10.1186/s40164-023-00441-y