ACT001 Relieves NMOSD Symptoms by Reducing Astrocyte Damage with an Autoimmune Antibody

Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system inflammatory demyelinating disease, the pathogenesis of which involves autoantibodies targeting the extracellular epitopes of aquaporin-4 on astrocytes. We neutralized the AQP4-IgG from NMOSD patient sera using synthesized AQ...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Hongen Li, Mo Yang, Honglu Song, Mingming Sun, Huanfen Zhou, Junxia Fu, Di Zhou, Wenhao Bai, Biyue Chen, Mengying Lai, Hao Kang, Shihui Wei
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	neuromyelitis optica aquaporin 4 mimotope ACT001 animal model
Online Access:	https://www.mdpi.com/1420-3049/28/3/1412