Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies

Abstract Peritoneal dialysis (PD) is considered a life-saving treatment for end-stage renal disease. However, prolonged PD use can lead to the development of peritoneal fibrosis (PF), diminishing its efficacy. Peritoneal mesothelial cells (PMCs) are key initiators of PF when they become damaged. Exp...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Fang Yu, Jia Chen, Xiaoyue Wang, Shihui Hou, Hong Li, Yaru Yao, Yani He, Kehong Chen
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Metabolic reprogramming Peritoneal mesothelial cells Peritoneal dialysis Peritoneal fibrosis Therapeutic target
Online Access:	https://doi.org/10.1186/s12964-025-02113-2