Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice

Background: Tauopathies such as Alzheimer’s disease (AD) are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau (MAPT) aggregating into neurofibrillary tangles (NFTs). O-linked β-N-acetylglucosamine (O-GlcNAc) modifications have been suggested to regulate tau ph...

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Bibliographic Details

Published in:	Journal of Integrative Neuroscience
Main Authors:	Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbracht
Format:	Article
Language:	English
Published:	IMR Press 2023-09-01
Subjects:	thiamet g rtg4510 oga hyperactivity tau pathology tauopathy
Online Access:	https://www.imrpress.com/journal/JIN/22/5/10.31083/j.jin2205135