Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3

17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is expressed at high levels in testes and seminal vesicles; it is also present in prostate tissue and involved in gonadal and non-gonadal testosterone biosynthesis. The enzyme is membrane-bound, and a crystal structure is not yet available. Selectiv...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Nigel Vicker, Helen V. Bailey, Joanna M. Day, Mary F. Mahon, Andrew Smith, Helena J. Tutill, Atul Purohit, Barry V. L. Potter
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	prostate cancer synthesis dehydrogenase homology modelling chiral chromatography X-ray crystallography
Online Access:	https://www.mdpi.com/1420-3049/26/23/7166