Bistability and oscillations in cooperative microtubule and kinetochore dynamics in the mitotic spindle

In the mitotic spindle microtubules attach to kinetochores via catch bonds during metaphase, and microtubule depolymerization forces give rise to stochastic chromosome oscillations. We investigate the cooperative stochastic microtubule dynamics in spindle models consisting of ensembles of parallel m...

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Bibliographic Details

Published in:	New Journal of Physics
Main Authors:	Felix Schwietert, Jan Kierfeld
Format:	Article
Language:	English
Published:	IOP Publishing 2020-01-01
Subjects:	mitotic spindle directional instability microtubule dynamics kinetochore oscillations bistability stochastic simulation
Online Access:	https://doi.org/10.1088/1367-2630/ab7ede