Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis

Abstract Background Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge due to their metastatic potential and limited treatment options. Raf kinase inhibitor protein (RKIP), a suppressor of the MAPK signaling pathway, is downregulated in various cancers and acts as a me...

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Bibliographic Details
Published in:	Cancer Cell International
Main Authors:	Nathália Cristina Campanella, Izabela Natalia Faria Gomes, Ana Laura Vieira Alves, Leticia Ferro Leal, Adriane Feijó Evangelista, Marcela Nunes Rosa, Matias Eliseo Melendez, Viviane Aline Oliveira Silva, Richard Lucas Konichi Dias, Lucas Faria Abrahão-Machado, Iara Santana, Olga Martinho, Denise Peixoto Guimarães, Vitor Marcel Faça, Rui Manuel Reis
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	RKIP expression Gene knockout GIST COL3A1 Collagen Cell invasion
Online Access:	https://doi.org/10.1186/s12935-023-03102-6

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