Hemorrhage-activated NRF2 in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance

Microscopic hemorrhage is a common aspect of cancers, yet its potential role as an independent factor influencing both cancer progression and therapeutic response is largely ignored. Recognizing the essential function of macrophages in red blood cell disposal, we explored a pathway that connects int...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Dominik J. Schaer, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Raphael M. Buzzi, Rok Humar, Elena Dürst, Florence Vallelian
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2024-02-01
Subjects:	Inflammation Oncology
Online Access:	https://doi.org/10.1172/JCI174528