Attenuation of natural killer cell cytotoxicity by interaction between NKp30 of NK cells and dipeptidase 1 of colon cancer cells

Abstract Natural killer (NK) cells play a crucial role in immune surveillance by recognizing and eliminating tumor cells. However, tumors employ various mechanisms to evade NK cell-mediated immunity. NKp30 is a potent activating receptor on NK cells, but its function can be inhibited by specific lig...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jong-Tae Kim, Eun Sun Park, Yo Sep Hwang, Hyang Ran Yoon, Suk Ran Yoon, Hee Jun Cho, Hee Gu Lee
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Subjects:	Natural cytotoxicity receptor NKp30 Dipeptidase 1 Natural killer cells Immunotherapy
Online Access:	https://doi.org/10.1038/s41598-025-18475-z