Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels

Abstract Background Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmodium knowlesi impacts Flt3L or DC in human malaria....

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Bibliographic Details

Published in:	Malaria Journal
Main Authors:	Jessica R. Loughland, Tonia Woodberry, Damian Oyong, Kim A. Piera, Fiona H. Amante, Bridget E. Barber, Matthew J. Grigg, Timothy William, Christian R. Engwerda, Nicholas M. Anstey, James S. McCarthy, Michelle J. Boyle, Gabriela Minigo
Format:	Article
Language:	English
Published:	BMC 2021-02-01
Subjects:	IBSM Plasmodium falciparum Plasmodium knowlesi Dendritic cells CD141 BDCA3
Online Access:	https://doi.org/10.1186/s12936-021-03642-0