Determination of Dapoxetine Hydrochloride in Human Plasma by HPLC–MS/MS and Its Application in a Bioequivalence Study

Dapoxetine is used for the treatment of premature ejaculation. The present study developed an HPLC–MS/MS method to determine the levels of dapoxetine in human plasma processed using simple protein precipitation. Dapoxetine-d<sub>7</sub> was selected as the internal standard. The establis...

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Bibliographic Details
Published in:Molecules
Main Authors: Xin Zhang, Zhanwang Gao, Fei Qin, Kehan Chen, Jiansong Wang, Lingli Wang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Subjects:
dapoxetine
method validation
HPLC–MS/MS
pharmacokinetic studies
Online Access:https://www.mdpi.com/1420-3049/27/9/2707

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https://www.mdpi.com/1420-3049/27/9/2707

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