pH Sensitive Erythrocyte-Derived Membrane for Acute Systemic Retention and Increased Infectivity of Coated Oncolytic Vaccinia Virus

Oncolytic viruses have emerged as a promising modality in cancer treatment given their high synergy with highly efficient immune checkpoint inhibitors. However, their potency is limited by their rapid in vivo clearance. To overcome this, we coated oncolytic vaccinia viruses (oVV) with erythrocyte-de...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Kaelan T. Samoranos, Alexandra L. Krisiewicz, Bianca C. Karpinecz, Philip A. Glover, Trevor V. Gale, Carla Chehadeh, Sheikh Ashshan, Richard Koya, Eddie Y. Chung, Han L. Lim
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Subjects:	cancer pH responsive cell membrane oncolytic virus vaccinia erythrocyte
Online Access:	https://www.mdpi.com/1999-4923/14/9/1810