Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids

ABSTRACT Nasal colonization by Staphylococcus aureus or Streptococcus pneumoniae is associated with an increased risk of infection by these pathobionts, whereas nasal colonization by Dolosigranulum species is associated with health. Human nasal epithelial organoids (HNOs) differentiated at air-liqui...

Full description

Bibliographic Details

Published in:	mSphere
Main Authors:	Andrea I. Boyd, Leah A. Kafer, Isabel F. Escapa, Amal Kambal, Hira Tariq, Susan G. Hilsenbeck, Hoa Nguyen-Phuc, Anubama Rajan, Joshua M. Lensmire, Kathryn A. Patras, Pedro A. Piedra, Sarah E. Blutt, Katherine P. Lemon
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-10-01
Subjects:	human nasal organoids HNO nasal colonization epithelial innate immune response bacterial colonization Dolosigranulum pigrum
Online Access:	https://journals.asm.org/doi/10.1128/msphere.00493-25