Lower pre-conditioning absolute lymphocyte counts are associated with worse outcomes in haploidentical stem cell transplantation with myeloablative regimen in children

BackgroundAnti-thymocyte globulin (ATG) is frequently administered for preventing graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In patients with low absolute lymphocyte count (ALC) before conditioning, weight-based dosing of ATG may cause overexp...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Kai Cui, Senlin Zhang, Yueke Du, Yutan Chai, Mingchu Liang, Shaoyan Hu, Jie Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	hematopoietic stem cell transplantation haploidentical anti-thymocyte globulin absolute lymphocyte counts pediatric
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1552263/full