Enhanced lactate accumulation upregulates PD‐L1 expression to delay neutrophil apoptosis in sepsis

Abstract Malfunction of neutrophil apoptosis and elevated serum lactate levels are the key cellular mechanism of immune suppressive status in septic patients. However, whether increased lactate affects apoptosis of neutrophils and aggravates sepsis development, and the molecular mechanism remain unk...

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Bibliographic Details

Published in:	View
Main Authors:	Miaomiao Fei, Hui Zhang, Fanbing Meng, Guanghui An, Jinxuan Tang, Jianbin Tong, Lize Xiong, Qidong Liu, Cheng Li
Format:	Article
Language:	English
Published:	Wiley 2024-02-01
Subjects:	inflammation lactate neutrophil apoptosis delay PD‐L1 sepsis
Online Access:	https://doi.org/10.1002/VIW.20230053