Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone

Abstract Giant cell tumor of bone (GCTB) is an aggressive osteolytic bone tumor characterized by the within-tumor presence of osteoclast-like multinucleated giant cells (MGCs), which are induced by the neoplastic stromal cells and lead to extensive bone destruction. However, the underlying mechanism...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Yunfei He, Dongdong Cheng, Cheng Lian, Yingjie Liu, Wenqian Luo, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Xue Zhang, Zhen Pan, Jinxi Lu, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Qingcheng Yang, Guohong Hu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Online Access:	https://doi.org/10.1038/s41419-021-04161-1