Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy

Abstract Background Dilation may be the first right ventricular change and accelerates the progression of threatening ventricular tachyarrhythmias and heart failure for patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), but the treatment for right ventricular dilation remains limi...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Mengxia Fu, Xiumeng Hua, Songren Shu, Xinjie Xu, Hang Zhang, Zhiming Peng, Han Mo, Yanyun Liu, Xiao Chen, Yicheng Yang, Ningning Zhang, Xiaohu Wang, Zirui Liu, Guangxin Yue, Shengshou Hu, Jiangping Song
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Subjects:	Arrhythmogenic right ventricular cardiomyopathy Single-cell RNA sequencing NLRP3
Online Access:	https://doi.org/10.1186/s12916-023-03232-8