The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity

Ferroptosis, a regulated form of cell death characterized by lipid peroxidation and iron accumulation, is increasingly recognized for its role in disease pathogenesis. The unfolded protein response (UPR) has been implicated in both endoplasmic reticulum (ER) stress and ferroptosis-mediated cell fate...

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書誌詳細

出版年:	Antioxidants
主要な著者:	Thu-Hang Thi Nghiem, Kim Anh Nguyen, Fedho Kusuma, Soyoung Park, Jeongmin Park, Yeonsoo Joe, Jaeseok Han, Hun Taeg Chung
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2025-03-01
主題:	ER stress ferroptosis PERK DDIT4 GPX4 unfolded protein response
オンライン･アクセス:	https://www.mdpi.com/2076-3921/14/3/307