Three steps toward dose optimization for oncology dose finding

Background: Traditional dose selection for oncology registration trials typically employs a one- or two-step single maximum tolerated dose (MTD) approach. However, this approach may not be appropriate for molecularly targeted therapy, which tends to have toxicity profiles that are markedly different...

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書誌詳細

出版年:	Contemporary Clinical Trials Communications
主要な著者:	Jason J.Z. Liao, Ekaterine Asatiani, Qingyang Liu, Kevin Hou
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2024-08-01
主題:	Dose finding Dose optimization Fractional factorial design Hybrid design MTD/MAD RDE
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2451865424000760