T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may per...
| 發表在: | Frontiers in Immunology |
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| Main Authors: | , , , , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Frontiers Media S.A.
2019-10-01
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| 主題: | |
| 在線閱讀: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02453/full |
| _version_ | 1851925091283107840 |
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| author | Christina M. Paluskievicz Xuefang Cao Reza Abdi Pan Zheng Pan Zheng Yang Liu Yang Liu Jonathan S. Bromberg Jonathan S. Bromberg Jonathan S. Bromberg |
| author_facet | Christina M. Paluskievicz Xuefang Cao Reza Abdi Pan Zheng Pan Zheng Yang Liu Yang Liu Jonathan S. Bromberg Jonathan S. Bromberg Jonathan S. Bromberg |
| author_sort | Christina M. Paluskievicz |
| collection | DOAJ |
| container_title | Frontiers in Immunology |
| description | Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may permit control of this pathologic suppression without interfering with homeostatic self-tolerance. This review will define the unique role of Treg in cancer growth, and the ways by which Treg inhibit a robust anti-tumor immune response. There will be specific focus placed on Treg homing to the tumor microenvironment (TME), TME formation of induced Treg (iTreg), mechanisms of suppression that underpin cancer immune escape, and trophic nonimmunologic effects of Treg on tumor cells. |
| format | Article |
| id | doaj-art-cf8d5dcbb6a34842b80544f76fec7969 |
| institution | Directory of Open Access Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-cf8d5dcbb6a34842b80544f76fec79692025-08-19T21:56:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-10-011010.3389/fimmu.2019.02453488694T Regulatory Cells and Priming the Suppressive Tumor MicroenvironmentChristina M. Paluskievicz0Xuefang Cao1Reza Abdi2Pan Zheng3Pan Zheng4Yang Liu5Yang Liu6Jonathan S. Bromberg7Jonathan S. Bromberg8Jonathan S. Bromberg9Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United StatesDivision of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United StatesCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, United StatesTreg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may permit control of this pathologic suppression without interfering with homeostatic self-tolerance. This review will define the unique role of Treg in cancer growth, and the ways by which Treg inhibit a robust anti-tumor immune response. There will be specific focus placed on Treg homing to the tumor microenvironment (TME), TME formation of induced Treg (iTreg), mechanisms of suppression that underpin cancer immune escape, and trophic nonimmunologic effects of Treg on tumor cells.https://www.frontiersin.org/article/10.3389/fimmu.2019.02453/fullTregimmunosuppressiontumor microenvironmentmetastasisanti-tumor immunity |
| spellingShingle | Christina M. Paluskievicz Xuefang Cao Reza Abdi Pan Zheng Pan Zheng Yang Liu Yang Liu Jonathan S. Bromberg Jonathan S. Bromberg Jonathan S. Bromberg T Regulatory Cells and Priming the Suppressive Tumor Microenvironment Treg immunosuppression tumor microenvironment metastasis anti-tumor immunity |
| title | T Regulatory Cells and Priming the Suppressive Tumor Microenvironment |
| title_full | T Regulatory Cells and Priming the Suppressive Tumor Microenvironment |
| title_fullStr | T Regulatory Cells and Priming the Suppressive Tumor Microenvironment |
| title_full_unstemmed | T Regulatory Cells and Priming the Suppressive Tumor Microenvironment |
| title_short | T Regulatory Cells and Priming the Suppressive Tumor Microenvironment |
| title_sort | t regulatory cells and priming the suppressive tumor microenvironment |
| topic | Treg immunosuppression tumor microenvironment metastasis anti-tumor immunity |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02453/full |
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