Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin

Shiga toxin (Stx) is an AB5 ribotoxin made by Stx-producing Escherichia coli (STEC). These organisms cause diarrhea, hemorrhagic colitis and the hemolytic uremic syndrome. STEC make two types of Stxs, Stx1 and/or Stx2. Stx2 has one prototype (a) and six subtypes (b–g), but only STEC that make Stx2a,...

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Bibliographic Details

Published in:	Toxins
Main Authors:	Joshua C. Bunger, Angela R. Melton-Celsa, Ernest L. Maynard, Alison D. O'Brien
Format:	Article
Language:	English
Published:	MDPI AG 2015-06-01
Subjects:	Shiga toxin Stx2 Stx2c Stx2d STEC
Online Access:	http://www.mdpi.com/2072-6651/7/6/2306