1-Nitropyrene disrupts testicular steroidogenesis via oxidative stress-evoked PERK-eIF2α pathway

Our previous study showed 1-Nitropyrene (1-NP) exposure disrupted testicular testosterone synthesis in mouse, but the exact mechanism needs further investigation. The present research found 4-phenylbutyric acid (4-PBA), an endoplasmic reticulum (ER) stress inhibitor, recovered 1-NP-induced ER stress...

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Bibliographic Details

Published in:	Ecotoxicology and Environmental Safety
Main Authors:	Xiu-liang Li, Yu-lin Liu, Jia-yu Liu, Yan-yan Zhu, Xin-xin Zhu, Wei-wei Zhang, Jian Li, Ye Zhao, Ling-li Zhao, Cheng Zhang, Hua Wang, De-xiang Xu, Lan Gao
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Subjects:	1-NP Testosterone ER stress PERK-eIF2α Antioxidant
Online Access:	http://www.sciencedirect.com/science/article/pii/S0147651323005316