Aging-related alternative splicing drive neoantigen emergence revealed by transcriptome analysis of 1,255 human blood samples

This study aimed to identify age-related genes and alternative splicing (AS) events by comprehensive transcriptome analysis of 1,255 healthy blood samples from individuals aged 8–87 years. We identified 1,029 up-regulated and 1,186 down-regulated genes in older individuals, including 17 genes overla...

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Bibliographic Details

Published in:	Frontiers in Aging
Main Authors:	Shuhan Li, Haohao Lv, Renxin Zhang, Jinjun Li, Zhiyuan Chen, Naixue Yang, Shaoxing Dai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	aging transcriptome analysis alternative splicing immunosenescence neoantigens anti-aging immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fragi.2025.1575862/full