Uncovering critical transitions and molecule mechanisms in disease progressions using Gaussian graphical optimal transport

Abstract Understanding disease progression is crucial for detecting critical transitions and finding trigger molecules, facilitating early diagnosis interventions. However, the high dimensionality of data and the lack of aligned samples across disease stages have posed challenges in addressing these...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Wenbo Hua, Ruixia Cui, Heran Yang, Jingyao Zhang, Chang Liu, Jian Sun
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Online Access:	https://doi.org/10.1038/s42003-025-07995-z