Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

Microglia, the resident CNS macrophages, have been implicated in the pathogenesis of Rett Syndrome (RTT), an X-linked neurodevelopmental disorder. However, the mechanism by which microglia contribute to the disorder is unclear and recent data suggest that microglia do not play a causative role. Here...

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Bibliographic Details

Published in:	eLife
Main Authors:	Dorothy P Schafer, Christopher T Heller, Georgia Gunner, Molly Heller, Christopher Gordon, Timothy Hammond, Yochai Wolf, Steffen Jung, Beth Stevens
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2016-07-01
Subjects:	microglia Rett Syndrome Mecp2 synapse engulfment
Online Access:	https://elifesciences.org/articles/15224