Baicalein Induces G₂/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells

Ovarian cancer is a lethal gynecological cancer because drug resistance often results in treatment failure. The CHK2, a tumor suppressor, is considered to be an important molecular target in ovarian cancer due to its role in DNA repair. Dysfunctional CHK2 impairs DNA damage-induced checkpoints, redu...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Tzu-Chao Chuang, Wei-Syun Shao, Shih-Chung Hsu, Shou-Lun Lee, Ming-Ching Kao, Vinchi Wang
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Subjects:	baicalein CHK2 DNA damage response flavone ovarian cancer pro-oxidant
Online Access:	https://www.mdpi.com/1420-3049/28/3/1039