Hypo-Osmotic Loading Induces Expression of IL-6 in Nucleus Pulposus Cells of the Intervertebral Disc Independent of TRPV4 and TRPM7

Painful intervertebral disc (IVD) degeneration is an age-related process characterized by reduced tissue osmolarity, increased catabolism of the extracellular matrix, and elevated levels of pro-inflammatory molecules. With the aging population and constantly rising treatment costs, it is of utmost i...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Aleksandra Sadowska, Birsen Altinay, Wolfgang Hitzl, Stephen J. Ferguson, Karin Wuertz-Kozak
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-07-01
Subjects:	intervertebral disc (IVD) osmolarity osmosensing transient receptor potential (TRP) channels inflammation degenerative disc disease (DDD)
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00952/full