Red blood cells capture and deliver bacterial DNA to drive host responses during polymicrobial sepsis

Red blood cells (RBCs), traditionally recognized for their role in transporting oxygen, play a pivotal role in the body’s immune response by expressing TLR9 and scavenging excess host cell-free DNA. DNA capture by RBCs leads to accelerated RBC clearance and triggers inflammation. Whether RBCs can al...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	L.K. Metthew Lam, Nathan J. Klingensmith, Layal Sayegh, Emily Oatman, Joshua S. Jose, Christopher V. Cosgriff, Kaitlyn A. Eckart, John McGinniss, Piyush Ranjan, Matthew Lanza, Nadir Yehya, Nuala J. Meyer, Robert P. Dickson, Nilam S. Mangalmurti
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2025-02-01
Subjects:	Inflammation Pulmonology
Online Access:	https://doi.org/10.1172/JCI182127