Dipeptidyl peptidase 4 deficiency improves survival after focal cerebral ischemia in mice and ameliorates microglia activation and specific inflammatory markers

Dipeptidyl peptidase 4 (DPP4; CD26) is involved in the regulation of various metabolic, immunological, and neurobiological processes in healthy individuals. Observations based on epidemiological data indicate that DPP4 inhibition by gliptins, typically used in patients with diabetes, may reduce the...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Corinna Höfling, Philippa Donkersloot, Luise Ulrich, Sina Burghardt, Michael Opitz, Stefanie Geissler, Stephan Schilling, Holger Cynis, Dominik Michalski, Steffen Roßner
Format:	Article
Language:	English
Published:	Elsevier 2024-10-01
Subjects:	Focal cerebral ischemia Dipeptidyl peptidase 4 CCL2 Gliosis Inflammation Chemokines
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996124002717