Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors

The status of lactate has evolved from being considered a waste product of cellular metabolism to a useful metabolic substrate and, more recently, to a signaling molecule. The fluctuations of lactate levels within biological tissues, in particular in the interstitial space, are crucial to assess wit...

Full description

Bibliographic Details

Published in:	Biosensors
Main Authors:	Joel Wellbourne-Wood, Marc Briquet, Maxime Alessandri, Francesca Binda, Maylis Touya, Jean-Yves Chatton
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Subjects:	lactate genetically encoded fluorescent indicator GPR81 HCAR1 circularly permuted green fluorescent protein
Online Access:	https://www.mdpi.com/2079-6374/12/3/143