PKM2 modulates chemotherapy sensitivity by regulating autophagy and predicts the prognosis and immunity in pancancer

Abstract One of the main characteristics of tumor metabolite reprogramming is enhanced glycolysis, and Pyruvate Kinase M2(PKM2) is a crucial enzyme that limits the pace of glycometabolism. Although PKM2 has been proven to affect the development of some cancers, a pan-cancer analysis of PKM2 has not...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Scientific Reports
المؤلفون الرئيسيون:	Haosheng Zheng, Jian Tan, Fei Qin, Yuzhen Zheng, Xingping Yang, Zui Liu, Weijie Cai, Xianyu Qin, Hongying Liao
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Portfolio 2025-04-01
الموضوعات:	PKM2; prognosis Tumor microenvironment Immune cell infiltration Immunotherapy Chemotherapy Pan-cancer
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-025-96562-x