Crystal Structure of Human CD47 in Complex with Engineered SIRPα.D1(N80A)

<b>Background:</b> Targeting the CD47/SIRPα signaling pathway represents a novel approach to enhance anti-tumor immunity. However, the crystal structure of the CD47/SIRPα has not been fully studied. This study aims to analyze the structure interface of the complex of CD47 and IMM01, a no...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang, Wenzhi Tian
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Subjects:	cancer immunotherapy SIRPα-Fc fusion proteins CD47/SIRPα crystal structure immune checkpoint pathway computer-aided drug discovery
Online Access:	https://www.mdpi.com/1420-3049/27/17/5574