Coordinated expansion of memory T follicular helper and B cells mediates spontaneous clearance of HCV reinfection

IntroductionFollicular helper T cells are essential for helping in the maturation of B cells and the production of neutralizing antibodies (NAbs) during primary viral infections. However, their role during recall responses is unclear. Here, we used hepatitis C virus (HCV) reinfection in humans as a...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Mohamed Eisa, Elsa Gomez-Escobar, Nathalie Bédard, Nourtan F. Abdeltawab, Nicol Flores, Sabrina Mazouz, Alizée Fieffé-Bédard, Patrick Sakayan, John Gridley, Mohamed S. Abdel-Hakeem, Julie Bruneau, Arash Grakoui, Naglaa H. Shoukry
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	hepatitis C virus B cells neutralizing antibodies Tfh and immunity reinfection
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1403769/full