Dravet syndrome: novel insights into SCN1A-mediated epileptic neurodevelopmental disorders within the molecular diagnostic-therapeutic framework

Dravet Syndrome (DS), a rare genetic encephalopathy characterized by severe drug-resistant epilepsy and progressive neurodevelopmental regression in infancy, is caused by de novo mutations in the SCN1A gene on chromosome 2q24 in over 80% of cases. This review synthesizes current insights into its mo...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Guirui Zhang, Shupeng Huang, Mingzhen Wei, Yongmo Wu, Zhengyi Xie, Jin Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	Dravet syndrom SCN1A GABAergic antisence oligonucleotides molecular
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1634718/full