Genome-scale model of Rothia mucilaginosa predicts gene essentialities and reveals metabolic capabilities

ABSTRACT Cystic fibrosis (CF), an inherited genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene, results in sticky and thick mucosal fluids. This environment facilitates the colonization of various microorganisms, some of which can cause acute and chr...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Nantia Leonidou, Lisa Ostyn, Tom Coenye, Aurélie Crabbé, Andreas Dräger
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-06-01
Subjects:	iRM23NL Rothia mucilaginosa DSM20746 ATCC 25296 constraint-based modeling flux balance analysis flux variability analysis
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.04006-23