IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy

Background/Aim: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Factor-1 (IGF-1) activity, a potent mitogen with vit...

Full description

Bibliographic Details

Published in:	Kidney & Blood Pressure Research
Main Authors:	Amal Al-Eisa, Gursev S. Dhaunsi
Format:	Article
Language:	English
Published:	Karger Publishers 2017-06-01
Subjects:	Mesangial cells IgA Nephropathy IGF-1 IGF-1 receptor
Online Access:	http://www.karger.com/Article/FullText/478736