Karyopherin-β2 Inhibits and Reverses Aggregation and Liquid-liquid Phase Separation of the ALS/FTD-Associated Protein FUS
The study of RNA-binding proteins (RBP) offers insight into the mechanisms of pathologic protein aggregation in neurodegenerative diseases. We developed a protocol for purifying an RBP FUS and a nuclear import receptor (NIR) Kapβ2 and testing the ability of Kapβ2 to mitigate FUS aggregation and liqu...
| Published in: | Bio-Protocol |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Bio-protocol LLC
2020-08-01
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| Online Access: | https://bio-protocol.org/en/bpdetail?id=3725&type=0 |