Protective Effects of Inhibition of Mitochondrial Fission on Organ Function After Sepsis

Sepsis-associated organ dysfunction plays a critical role in its high mortality, mainly in connection with mitochondrial dysfunction. Whether the inhibition of mitochondrial fission is beneficial to sepsis-related organ dysfunction and underlying mechanisms are unknown. Cecal ligation and puncture i...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Yu Zhu, Lei Kuang, Yue Wu, Haoyue Deng, Han She, Yuanqun Zhou, Jie Zhang, Liangming Liu, Tao Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Subjects:	mitochondrial fission Mdivi-1 Drp1 sepsis organ function
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.712489/full