The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration

Abstract Background Metabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism. Pancreatic neoplastic lesions evolve within a dense desmoplastic stroma, consisting in abundant extracellular matrix...

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出版年:	Journal of Experimental & Clinical Cancer Research
主要な著者:	Chiara Cencioni, Silvia Malatesta, Virginia Vigiano Benedetti, Valerio Licursi, Livia Perfetto, Federica Conte, Danilo Ranieri, Armando Bartolazzi, Martina Kunkl, Loretta Tuosto, Alberto Larghi, Geny Piro, Antonio Agostini, Giampaolo Tortora, Vincenzo Corbo, Carmine Carbone, Francesco Spallotta
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-01-01
主題:	Pancreatic ductal adenocarcinoma Cancer associated fibroblasts Diabetes Obesity Collagen deposition
オンライン･アクセス:	https://doi.org/10.1186/s13046-024-03263-w