CSFV restricts necroptosis to sustain infection by inducing autophagy/mitophagy-targeted degradation of RIPK3

ABSTRACT As an essential component of host defense against infection, necroptosis is a novel highly regulated mode of cell death that is mediated by signaling complexes containing receptor-interacting protein kinase 1 (RIPK1) and RIPK3. Lymphocyte depletion and immunosuppression are typical clinical...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Keke Wu, Bingke Li, Xiaoai Zhang, Yiqi Fang, Sen Zeng, Wenshuo Hu, Xiaodi Liu, Xueyi Liu, Zhimin Lu, Xiaowen Li, Wenxian Chen, Yuwei Qin, Bolun Zhou, Linke Zou, Feifan Zhao, Lin Yi, Mingqiu Zhao, Shuangqi Fan, Jinding Chen
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-01-01
Subjects:	autophagy necroptosis CSFV NS4A TRIM25 mitophagy
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02758-23